Combination of Topical Use of a Thrombin-Based Hemostatic Matrix and Tranexamic Acid does not have a Synergic Effect on Reducing Postoperative Blood Loss in Minimally Invasive Total Knee Arthroplasty. A Prospective Randomized Controlled Study

Background: There is limited information regarding the blood-conservation effect of combined topical Tranexamic Acid (TXA) and Thrombin-Based Hemostatic Matrix (TBHM) in Total Knee Arthroplasty (TKA). This study to evaluate whether there synergic use TXA TBHM reduce blood loss during TKA. Materials Methods: Sixty-nine patients (69 knees) who underwent primary TKA were randomly assigned into a group (n=34), received intra-articular administration 3g 60mL saline, + (n=35), (3g) saline after The outcomes Blood Loss (TBL) postoperative Hemoglobin (Hb) level. Secondary included transfusion rate incidence Venous Thromboembolism (VTE). Results: mean TBL was 678 ± 203 mL , which similar that only at 733 217 (p=0.276). no differences Hb level between two groups. (2.9% versus 0%, p=0.242). No either developed VTE within 3 months. Conclusions: Our prospective randomized controlled did not show undergoing Further investigation with larger sample size may be required.